Researchers from Shanghai Jiao Tong University conducted a study that found that two substances from a group known as "forever chemicals" — perfluorononanoic acid (PFNA) and perfluorooctanesulfonamide (PFOSA) — may contribute to accelerated biological aging in men aged 50 to 64. This information was published on the Lenta.ru website, citing the journal Frontiers in Aging.
PFAS (per- and polyfluoroalkyl substances) have been dubbed "forever chemicals." These synthetic substances are used in non-stick coatings, water-repellent fabrics, packaging, and fire-fighting foams. Due to their high resistance to degradation, they accumulate in the environment, including water, soil, and the human body. It has previously been established that some of these substances may increase the risk of cancer, obesity, infertility, and hormonal disorders.
During the study, scientists analyzed data from 326 participants who underwent the National Health and Nutrition Examination Survey in the United States in 1999-2000. The concentration of 11 PFAS was measured in blood samples from the subjects, and DNA methylation — changes that affect gene activity — was assessed. The researchers used 12 models of "epigenetic clocks" to calculate the biological age of the participants and compare it with their chronological age.
PFNA and PFOSA were found in the blood of 95% of the study participants, and higher levels of these chemicals showed a statistically significant association with accelerated epigenetic aging in men. Notably, no such association was found in women.
The researchers suggest that middle age in men may be particularly susceptible to the effects of external stressors. Lifestyle factors, such as smoking, may also influence aging indicators, exacerbating the negative impact of chemical pollutants.
It was previously stated by the FMBA that aging begins to manifest in humans as early as 25 years old.
